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The PSD, PSD+RibCys, PSD+Zn, PSD+RibCys+Zn, and Control groups were sleep-deprived only, sleep-deprived and given 100mg/kg body-weight of pure RibCys, sleep-deprived and given 10mg/kg body weight Zn, sleep-deprived and given a combination of 100mg/kg of RibCys and 10mg/kg of Zn, and given distilled water without sleep deprivation, respectively

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This clinical review found that oral vitamin B12 absorption is capped by a saturable intrinsic-factor pathway (roughly 50–60% of a small dose, limited to about 1.5–2.5 mcg per meal) plus a small passive-diffusion component (about 1%), a ceiling that intramuscular injection bypasses by delivering B12 directly into the bloodstream.